IDH-Mutant Tumors Vulnerable to PARP Inhibition

Abstract Several cancers, including glioma and acute myeloid leukemia, carry mutations in IDH1 or IDH2. Researchers have found that these mutations impair homologous recombination, making the tumors sensitive to PARP inhibition. They showed that one such inhibitor, olaparib, killed IDH1/2-mutant cancer cells in culture and slowed tumor growth in mice.