聚乙二醇
氧化还原
材料科学
氧化酶试验
化学
癌症研究
葡萄糖氧化酶
医学
生物化学
纳米技术
酶
生物传感器
有机化学
作者
Ze Wang,Lu Wang,Shuwei Liu,Mengsi Zhang,Yunfeng Li,Rong Li,Yi Liu,Hao Zhang
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:14 (6): 2186-2198
被引量:6
摘要
Although many semiconductor heterojunctions have been prepared to promote radiation-generated exciton separation for radiocatalysis therapy (RCT), most of them inevitably sacrifice the redox ability of radiation-generated electrons and holes. Herein, we design and construct BiOI/Bi2S3@polydopamine nanosheets modified by amine-polyethylene glycol-folic acid and glucose oxidase for glucose oxidase-sensitized RCT and starvation therapy (ST) synergistic therapy of tumors. The unique Z-scheme energy level arrangement between BiOI and Bi2S3 can elevate the charge separation efficiency, as well as maximize the redox ability of radiation-generated electrons and holes, leading to the enhancement of the therapeutic efficacy of RCT. Since glucose oxidase can supply excess H2O2 for RCT to produce ˙OH on one hand, but efficiently cut off the energy supply of tumor cells via ST, on the other hand, our nanosheets exhibit superior tumor therapeutic efficacy to any single treatment benefiting from the cascade and synergy effects between RCT and ST.
科研通智能强力驱动
Strongly Powered by AbleSci AI