免疫球蛋白E
免疫学
肥大细胞
佐剂
免疫系统
生物
效应器
过敏
获得性免疫系统
锡克
内生
抗体
信号转导
细胞生物学
酪氨酸激酶
内分泌学
作者
Yasmeen S. El Ansari,Cynthia Kanagaratham,Owen L. Lewis,Hans C. Oettgen
出处
期刊:Advances in Immunology
日期:2020-01-01
卷期号:: 93-153
被引量:6
标识
DOI:10.1016/bs.ai.2020.10.003
摘要
Mast cells and IgE are most familiar as the effectors of type I hypersensitivity reactions including anaphylaxis. It is becoming clear however that this pair has important immunomodulatory effects on innate and adaptive cells of the immune system. In this purview, they act as endogenous adjuvants to ignite evolving immune responses, promote the transition of allergic disease into chronic illness and disrupt the development of active mechanisms of tolerance to ingested foods. Suppression of IgE-mediated mast cell activation can be exerted by molecules targeting IgE, FcɛRI or signaling kinases including Syk, or by IgG antibodies acting via inhibitory Fcγ receptors. In 2015 we reviewed the evidence for the adjuvant functions of mast cells. This update includes the original text, incorporates some important developments in the field over the past five years and discusses how interventions targeting these pathways might have promise in the development of strategies to treat allergic disease.
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