光热治疗
纳米颗粒
声动力疗法
细胞内
普鲁士蓝
纳米技术
材料科学
生物物理学
癌细胞
生物相容性材料
超声波
化学
生物医学工程
癌症
生物化学
医学
内科学
放射科
物理化学
生物
电化学
电极
作者
Xian Shu,Yi Chen,Ping Yan,Yun Xiang,Qun-Ying Shi,Tinghui Yin,Ping Wang,Li‐Han Liu,Xintao Shuai
标识
DOI:10.1016/j.jconrel.2022.05.010
摘要
Downregulation of adenosine triphosphate (ATP)-dependent heat shock proteins (HSPs) can significantly reduce the tumorigenicity of cancer cells and overcome heat endurance to achieve high-performance mild temperature (≤45 °C) photothermal therapy (PTT). Herein, we designed and constructed 4T1 cancer cell membrane-coated, lonidamine (LN)-loaded and DL-menthol (DLM)-loaded hollow mesoporous Prussian blue nanoparticles (PBLM@CCM NPs). DLM with mild phase change characteristics served as a plugging agent to avoid early leakage and allow thermally controllable release of LN, which enabled selective intracellular delivery of LN to reduce the HSPs and overcome the heat endurance in PTT by inhibiting the generation of intracellular ATP. The biocompatible PBLM@CCM NPs with good tumor targeting efficiency achieved high-efficiency mild temperature PTT. Meanwhile, PBLM@CCM NPs could allow photoacoustic (PA) imaging and generate heat to promote the phase change of DLM for ultrasound (US) imaging, which is of great value for future clinical translational studies.
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