细胞外基质
生物物理学
粘附
细胞粘附
纤维连接蛋白
细胞骨架
基质(化学分析)
细胞迁移
作者
Masha Prager-Khoutorsky,Alexandra Lichtenstein,Ramaswamy Krishnan,Kavitha Rajendran,Avi Mayo,Zvi Kam,Benjamin Geiger,Alexander D. Bershadsky
摘要
Bershadsky and colleagues show that fibroblast polarization depends on matrix rigidity and focal adhesion mechanosensing. They target protein tyrosine kinases through RNAi to identify signalling molecules that regulate traction force generation, focal adhesion assembly and mechanosensitivity.
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