单纯疱疹病毒
体外
细胞毒性
化学
三萜类
立体化学
传统医学
生物
病毒学
生物化学
病毒
医学
作者
Ángel Caunedo Álvarez,Solomon Habtemariam,Francisco Parra
标识
DOI:10.1080/14786419.2015.1007456
摘要
The cytotoxicity and antiviral properties of Bursera simaruba against herpes simplex viruses (HSV-1 and HSV-2) were investigated through a bioactivity-guided isolation protocol. The plant material was fractionated using solvent-solvent partitioning, size-exclusion and thin-layer chromatography. The antiviral compounds present in the most active fractions were identified by means of LC-MS and NMR. Three different methods were compared during the evaluation of antiviral activity of samples. Four lupene-related pentacyclic triterpenes were found to be responsible for the anti-herpesvirus effects of B. simaruba and were isolated from this species for the first time. The selective indexes (SI) of B. simaruba-derived samples ranged from 7.7 to 201.9.
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