医学
胃泌素瘤
疾病
佐林格-埃里森综合征
病因学
幽门螺杆菌
胃肠病学
肝病学
胃出口梗阻
胃酸
内科学
消化性
消化性溃疡
质子抑制剂泵
普通外科
胃
分泌物
胃泌素
作者
James L. Guzzo,Mona Duncan,Barbara L. Bass,Grant V. Bochicchio,Lena M. Napolitano
标识
DOI:10.1007/s10620-005-2999-5
摘要
The recognition of Helicobacter pylori infection as a cause of peptic ulcer disease, medical regimens to eradicate the organism, and the widespread use of proton pump inhibition to suppress gastric acid secretion have revolutionized the management of peptic ulcer disease. As a result, successful medical management of peptic ulcer disease has largely supplanted the need for gastric surgery by general surgeons. Surgery is reserved for complications of the disease, refractory disease, or rare causes of ulcer disease such as gastrinoma and Zollinger–Ellison syndrome. In this report, we describe a case of intractable peptic ulcer disease that progressed to gastric outlet obstruction despite maximal medical therapy. We review the diagnostic studies utilized to evaluate the potential etiologies of peptic ulcer disease and the difficulty in diagnosing gastrinoma and Zollinger–Ellison in the setting of potent medical acid suppression therapy.
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