HIF1A型
血管生成
Gα亚单位
缺氧(环境)
癌症研究
缺氧诱导因子
缺氧诱导因子1
肿瘤进展
生物
病理生理学
糖酵解
癌症
医学
蛋白质亚单位
基因
内科学
内分泌学
转录因子
化学
新陈代谢
氧气
有机化学
生物化学
标识
DOI:10.1016/s1471-4914(02)02317-1
摘要
Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and metabolic adaptation to hypoxia (via glycolysis). HIF-1 consists of a constitutively expressed HIF-1 beta subunit and an oxygen- and growth-factor-regulated HIF-1 alpha subunit. In xenografts, tumor growth and angiogenesis are correlated with HIF-1 expression. In human cancers, HIF-1 alpha is overexpressed as a result of intratumoral hypoxia and genetic alterations affecting key oncogenes and tumor suppressor genes. HIF-1 alpha overexpression in biopsies of brain, breast, cervical, esophageal, oropharyngeal and ovarian cancers is correlated with treatment failure and mortality. Increased HIF-1 activity promotes tumor progression, and inhibition of HIF-1 could represent a novel approach to cancer therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI