血小板
巨核细胞
血小板生成素
化学
巨核细胞生成
细胞生物学
骨髓
内科学
血小板活化
造血
生物
血小板生成素
内分泌学
医学
作者
Rudy Fuentes,Yuhuan Wang,Jessica Hirsch,Cheng Wang,Lubica Rauova,G. Scott Worthen,M. Anna Kowalska,Mortimer Poncz
摘要
Thrombopoiesis, the process by which circulating platelets arise from megakaryocytes, remains incompletely understood. Prior studies suggest that megakaryocytes shed platelets in the pulmonary vasculature. To better understand thrombopoiesis and to develop a potential platelet transfusion strategy that is not dependent upon donors, of which there remains a shortage, we examined whether megakaryocytes infused into mice shed platelets. Infused megakaryocytes led to clinically relevant increases in platelet numbers. The released platelets were normal in size, displayed appropriate surface markers, and had a near-normal circulating half-life. The functionality of the donor-derived platelets was also demonstrated in vivo. The infused megakaryocytes mostly localized to the pulmonary vasculature, where they appeared to shed platelets. These data suggest that it may be unnecessary to generate platelets from ex vivo grown megakaryocytes to achieve clinically relevant increases in platelet numbers.
科研通智能强力驱动
Strongly Powered by AbleSci AI