Comparsion between Curative effects of Methylprednisolone and Dexamethasone on Radiation Cerebral Edema

Objective To compare the curative effect of methylprednisolone on radiative cerebral edema with dexamethasone. Methods The intracranial glioma models were established in 100 rats who were divided into groups A (large dose methylprednisolone),B (small dose methylprednisolone),C (dexamethasone),D (control,being irradiated,but not given drugs),and E (blank,not irradiated and not given drugs). The brains were irradiated by Co60 15 days after the implantation of glioma cells in groups A,B,C and D. The content of cerebral water was determined. Results The content of cerebral water in group D was significantly higher than that in groups A,B,C and E (P0.05). The content of cerebral water in group C was significantly higher than that in groups A and B (P0.05). There were no significant difference in the content of cerebral water between group A and B (P0.05). Conclusions Methylprednisolone and dexamethasone can effectively decrease radiation cerebral edema,and the curative effect of methylprednisolone on the radiation cerebral edema is better than that of dexamethasone.