孟德尔随机化
医学
观察研究
因果关系(物理学)
混淆
因果关系
孟德尔遗传
因果推理
疾病
重症监护医学
生物信息学
遗传学
遗传变异
内科学
病理
基因型
基因
物理
法学
生物
量子力学
政治学
作者
Philip C Robinson,Hyon K. Choi,Ron Do,Tony R. Merriman
标识
DOI:10.1038/nrrheum.2016.102
摘要
Establishing causality of risk factors is important to determine the pathogenetic mechanisms underlying rheumatic diseases, and can facilitate the design of interventions to improve care for affected patients. The presence of unmeasured confounders, as well as reverse causation, is a challenge to the assignment of causality in observational studies. Alleles for genetic variants are randomly inherited at meiosis. Mendelian randomization analysis uses these genetic variants to test whether a particular risk factor is causal for a disease outcome. In this Review of the Mendelian randomization technique, we discuss published results and potential applications in rheumatology, as well as the general clinical utility and limitations of the approach.
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