Influence of DangGui and Its Compatibility on Immune Organs and Phagocytic Function of Mice Induced by Cyclophosphamide

Objective:To screen the optimal couplet medicines for DangGui(Radix Angelicae Sinensis) through observing its effects and the compatibility on immune organs and macrophage phagocytic function in hypoimmunologic mice caused by cyclophosphamide.Method:All 270 mice were divided into three batches,90 mice each batch.Each batch were randomized into blank control group,the model group,DangGui group,group of DangGui and BaiShao(White Paeony Root),Group of DangGui and ShuDiHuang(Chinese Foxglove),group of DangGui and ZhiShouWu(radix polygoni multiflori preparata),group of DangGui and RenShen(panax ginseng C.A.Mey),group of DangGui and DangShen(root of pilose asiabell) as well as group of DangGui and HuangQi(Leguminosae).Except blank control group,mice in other groups received peritoneal injection with cyclophosphamide to establish hypoimmunologic models.All indexes including spleen index,thymus index,peritoneal macrophage phagocytic rate,carbon clearance index and others were detected after intragastric administration for eight consecutive days.Result:Compared with the model group,spleen index,thymus index,peritoneal macrophage phagocytic rate,carbon clearance index of DangGui group and the groups of DangGui couplet medicines increased significantly(P0.05).Compared with DangGui group,spleen index and carbon clearance index in group of DangGui RenShen and group of DangGui DangShen raised obviously(P0.05),spleen index,peritoneal macrophage phagocytic rate,carbon clearance index were improved remarkably in group of DangGui and HuangQi(P0.05).Thymusindex,macrophagephagocyticrate,carbonclearanceindexingroupof DangGui and Baishao were raised obviously compared with the model group(P0.05),but lower than that of normal group(P0.05).Conclusion:DangGui and its couplet medicines could enhance immune function of hypoimmunologic mice and protect the body suffering from immune imbalance.The optimal couplet medicines of DangGui were with RenShen,DangShen and HuangQi.