Study on serum folic acid and vitamin B12 levels of patients with depression

Objective:To explore the changes of serum folic acid and vitamin B12 levels in patients with depression. Method:76 outpatients who met the diagnosis of 10th edition of International Classification Disease for depression.Whose courses lasted at least six months.67 healthy adults were served as controls.Serum folic acid and vitamin B12 levels were examined for all the subjects. Results:There was not statistically significant differences in mean serum folic acid levels and the occurence of low serum folic acid levels between two groups(P0.05).The mean serum vitamin B12 level was significantly lower (P0.05),and the occurence of low serum vitamin levels was significantly higher in the depression group(P0.01). Conclusion:Depression has some relationship with vitamin B12 deficiency,but no relationship with folic acid.