Objective:To study the clinical value of high-frequency ultrasonography on observing the acute crush injury of sciatic nerve in rabbits.Methods: A total of 16 rabbits were randomly divided into four groups according to different observation time.Models of acute crush injury of sciatic nerve in rabbits were established,and were (observed)by high-frequency ultrasonography 1,2,4 and 8 weeks respectively after damage.The internal radius of bilateral sciatic nerves were measured on the same levels.Results:The echoism and internal radius of sciatic nerves were changed after the acute crush injury.The change was consistent to the dynamic change of the degeneration and regeneration of nerve and the function of limbs after damage.Conclusion:High-frequency ultrasonography reflects the course of nerve degeneration and regeneration straightly,which provides a new morphological diagnostic method for peripheral nerve damage.