The clinical significance on the combined detection of the serum BNP,hs-CRP,cTnI and UA in heart failure

Objective To investigate the clinical significance on the combined detection of B-type natriuretic peptide(BNP),high sensitive C reactive protein(hs-CRP),cardiac troponin I(cTnI)and uric acid(UA) in the diagnosis of heart failure(HF).Methods The serum levels of BNP,hs-CRP,cTnI and UA in 292 patients with different etiological factors and grades of HF[according to the cardiac function standard of New York Heart Association(NYHA) Ⅰ-Ⅳ] and 100 healthy controls were determined.The sensitivity and specificity of 4 parameters were evaluated by receiver operating characteristic(ROC) curve.Results The levels of BNP,hs-CRP,cTnI and UA in different grades of HF had statistical significance(P0.05).In addition,the grade was worse,and its concentration was higher.The levels of BNP and hs-CRP showed statistical significance between HF NYHA I grade patients and healthy controls(P0.05),and the levels of cTnI and UA had no statistical significance between the healthy controls and HF NYHAⅠ grade patients(P0.05).The sensitivity of combined detection was 90.1% in early HF diagnosis,which was higher significantly than that of the individual detection(P0.01).Conclusions The significant clinical significance on the combined detection of the serum BNP,hs-CRP,cTnI and UA provides reference support in the diagnosis of early HF.