适体
膜
膜蛋白
嵌合体(遗传学)
化学
蛋白质降解
溶酶体
细胞
细胞生物学
计算生物学
生物化学
生物
分子生物学
酶
基因
作者
Yanyan Miao,Qianqian Gao,Menghan Mao,Chao Zhang,Liqun Yang,Yang Yang,Da Han
标识
DOI:10.1002/anie.202102170
摘要
Abstract The ability to regulate membrane protein abundance offers great opportunities for developing therapeutic sites for various diseases. Herein, we describe a platform for the targeted degradation of membrane‐associated proteins using bispecific aptamer chimeras that bind both the cell‐surface lysosome‐shuttling receptor (IGFIIR) and the targeted membrane‐bound proteins of interest. We demonstrate that the aptamer chimeras can efficiently and quickly shuttle the therapeutically relevant membrane proteins of Met and PTK‐7 to lysosomes and degrade them through the lysosomal protein degradation machinery. We anticipate that our method will provide a universal platform for the use of readily synthesized aptamer materials for biochemical research and potential therapeutics.
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