类有机物
代谢组学
蛋白质组学
计算生物学
转录组
生物
个性化医疗
体内
系统生物学
功能基因组学
基因组学
细胞生物学
生物信息学
基因
遗传学
基因组
基因表达
作者
Constantine A Simintiras,Pramod Dhakal,Chaman Ranjit,Harriet C. Fitzgerald,Ahmed Z. Balboula,Thomas E. Spencer
标识
DOI:10.1073/pnas.2026804118
摘要
Significance The ability to robustly isolate intraorganoid fluid in a high-throughput capacity, using human endometrial epithelia as a model, circumvents several constraints typically associated with obtaining biological fluids, both in vivo and in vitro. This approach also allows for direct tandem genomics, transcriptomics, proteomics, and functional metabolomics. In addition to enhancing our understanding of uterine fluid composition regulation, this innovation is directly and readily transferrable to wider fields of cell and organoid biology, with implications for personalized, or precision, medicine approach development.
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