氟康唑
蜡螟
白色念珠菌
两性霉素B
微生物学
毒力
生物
白色体
抗真菌药
酮康唑
药理学
抗真菌
生物化学
基因
作者
Min Pan,Qirui Wang,Ting Cheng,Daqiang Wu,Tianming Wang,Yan Ge,Jing Shao
出处
期刊:Biofouling
[Informa]
日期:2021-09-14
卷期号:37 (8): 922-937
被引量:5
标识
DOI:10.1080/08927014.2021.1985473
摘要
This study aimed to evaluate the mono- and dual- antifungal activities of paeonol (PAE) and fluconazole (FLZ)/amphotericin B (AmB). To this end, the effects of PAE and FLZ/AmB on cell surface hydrophobicity, hydrolase activity, morphological transition were investigated in vitro and in a Galleria mellonella infection model. The results showed a relatively high minimum inhibitory concentration (MIC) and sessile MIC (SMIC) of PAE alone. However, compared with the single drug, the combined use of PAE and FLZ/AmB had a potent synergistic potential to inhibit the virulence factors for Candida. The concomitant use of two drugs was consistently more effective than either drug alone for increasing survival rate, decreasing the fungal burden, and alleviating the pathological features of G. mellonella infected by the fungus. Taken together, these findings demonstrate the anti-Candida effects of PAE plus FLZ/AmB and their potential to increase the sensitivity of C. albicans to FLZ/AmB of PAE.
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