哮喘
医学
三卤甲烷
溴仿
横断面研究
环境卫生
全国健康与营养检查调查
优势比
烟草烟雾
人口
逻辑回归
内科学
化学
病理
氯
有机化学
氯仿
色谱法
作者
Yang Sun,Peng‐Fei Xia,Jing Xie,Vicente Mustieles,Yu Zhang,Yi‐Xin Wang,Carmen Messerlian
出处
期刊:The European respiratory journal
[European Respiratory Society]
日期:2021-10-08
卷期号:59 (5): 2101440-2101440
被引量:9
标识
DOI:10.1183/13993003.01440-2021
摘要
Population studies show that the use of swimming pools is associated with the risk of asthma and allergic diseases among children. Our objective was to explore the associations between blood trihalomethane (THM) concentrations and asthma among US adolescents, and assess to what extent the association is modified by active tobacco smoke exposure.We included 2359 adolescents aged 12-19 years with measured blood concentrations of chloroform (trichloromethane (TCM)), bromodichloromethane (BDCM), dibromochloromethane (DBCM) and bromoform (tribromomethane (TBM)) from the National Health and Nutrition Examination Survey 2005-2012. Logistic regression models were fitted to assess the odds ratios for the association of blood THM concentrations (three or four categories) with the risk of self-reported current and ever (lifetime) asthma.Blood DBCM concentrations were associated with a higher risk of ever asthma among all adolescents (OR 1.54 (95% CI 1.07-2.21), comparing the extreme exposure categories). The relationship was stronger among adolescents exposed to tobacco smoke (OR 3.96 (95% CI 1.89-8.30), comparing the extreme exposure categories). We also found positive relationships between blood brominated THM concentrations (sum of BDCM, DBCM and TBM) and risk of ever asthma and between blood DBCM and brominated THM concentrations and risk of current asthma among adolescents with tobacco smoke exposure. The relative excess risk of ever asthma due to the interaction between high blood DBCM and brominated THM concentrations and tobacco smoke exposure was 1.87 (95% CI 0.30-3.43) and 0.78 (95% CI 0.07-1.49), respectively.Exposure to THMs is associated with a higher risk of asthma in adolescents, particularly among those exposed to tobacco smoke.
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