毒力
群体感应
铜绿假单胞菌
生物膜
绿脓素
微生物学
群体猝灭
生物
重新调整用途
自诱导物
抗生素
抗生素耐药性
抗菌剂
病菌
细菌
基因
遗传学
生态学
作者
Jatin Chadha,Kusum Harjai,Sanjay Chhibber
标识
DOI:10.1111/1751-7915.13981
摘要
Unregulated consumption and overexploitation of antibiotics have paved the way for emergence of antibiotic-resistant strains and 'superbugs'. Pseudomonas aeruginosa is among the opportunistic nosocomial pathogens causing devastating infections in clinical set-ups globally. Its artillery equipped with diversified virulence elements, extensive antibiotic resistance and biofilms has made it a 'hard-to-treat' pathogen. The pathogenicity of P. aeruginosa is modulated by an intricate cell density-dependent mechanism called quorum sensing (QS). The virulence artillery of P. aeruginosa is firmly controlled by QS genes, and their expression drives the aggressiveness of the infection. Attempts to identify and develop novel antimicrobials have seen a sharp rise in the past decade. Among different proposed mechanisms, a novel anti-virulence approach to target pseudomonal infections by virtue of anti-QS and anti-biofilm drugs appears to occupy the centre stage. In this respect, bioactive phytochemicals have gained prominence among the scientific community owing to their significant quorum quenching (QQ) properties. Recent studies have shed light on the QQ activities of various phytochemicals and other drugs in perturbing the QS-dependent virulence in P. aeruginosa. This review highlights the recent evidences that reinforce the application of plant bioactives for combating pseudomonal infections, their advantages and shortcomings in anti-virulence therapy.
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