Safety, Health, and Environment (SHE) and human performance excellence are essential elements of Operational Excellence that contribute to and cross all functions. SHE and human performance excellence are mandatory to gain the working culture, commitment, and ownership required for successful Operational Excellence. Business-focused Operational Excellence strategies may initially appear to present daunting challenges to industrial operations. Coordinating efforts within Operational Excellence, partitioning the overall strategy into areas of individual control, and demanding safety, human, and work performance excellence will generate the required results. Minimizing SHE and operational risk requires identifying potential sources of risk and developing safe and solid procedures that can be applied when precursors to a potential incident are identified. Everyone must be trained to fully consider the risk during any abnormal event requiring decisions under pressures of time. Taken together, safety, human, and operating excellence provide the results necessary for world-class performance.