Predictive factors of axillary pathological complete response in HER2-positive breast cancer patients treated with neoadjuvant chemotherapy

QuestionIdentifying predictive factors for axillary pCR in HER2+ breast cancer patients undergoing NAC. FindingsAxillary radiological complete response predicted axillary pCR in univariate (p = 0.021) and multivariate analyses (p = 0.025), while Ki-67 was marginally significant in the multivariate model (p = 0.045). Clinical relevanceRecognizing reliable predictors of axillary pCR may support the omission of ALND in selected HER2+ patients, minimizing surgical morbidity.