失调
普氏粪杆菌
厚壁菌
真细菌
微生物群
肠道菌群
放线菌门
双歧杆菌
拟杆菌
生物
蔷薇花
梭杆菌
微生物学
胃肠病学
蛋白质细菌
粪便
内科学
胰腺炎
作文(语言)
免疫学
乳酸菌
细菌
16S核糖体RNA
遗传学
作者
Chunhua Zhou,Yuting Meng,Jiajia Xu,Fang Xue,Jiulong Zhao,Wei Zhou,Jianhua Zhao,Ji-Chen Han,Ling Zhang,Kaixuan Wang,Liang‐Hao Hu,Zhuan Liao,Wenbin Zou,Zhao‐Shen Li,Duowu Zou
出处
期刊:Pancreatology
[Elsevier]
日期:2020-01-01
卷期号:20 (1): 16-24
被引量:42
标识
DOI:10.1016/j.pan.2019.11.013
摘要
Gut microbiota alterations in chronic pancreatitis (CP) are seldomly described systematically. It is unknown whether pancreatic exocrine insufficiency (PEI) and different etiologies in patients with CP are associated with gut microbiota dysbiosis.The fecal microbiota of 69 healthy controls (HCs) and 71 patients with CP were compared to investigate gut microbiome alterations in CP and the relationship among gut microbiome dysbiosis, PEI and different etiologies. Fecal microbiomes were analyzed through 16S ribosomal RNA gene profiling, based on next-generation sequencing. Pancreatic exocrine function was evaluated by determining fecal elastase 1 activity.Patients with CP showed gut microbiota dysbiosis with decreased diversity and richness, and taxa-composition changes. On the phylum level, the gut microbiome of the CP group showed lower Firmicutes and Actinobacteria abundances than the HC group and higher Proteobacteria abundances. The abundances of Escherichia-Shigella and other genera were high in gut microbiomes in the CP group, whereas that of Faecalibacterium was low. Kyoto Encyclopedia of Genes and Genomes pathways (lipopolysaccharide biosynthesis and bacterial invasion of epithelial cells) were predicted to be enriched in the CP group. Among the top 5 phyla and 8 genera (in terms of abundance), only Fusobacteria and Eubacterium rectale group showed significant differences between CP patients, with or without PEI. Correlation analysis showed that Bifidobacterium and Lachnoclostridium correlated positively with fecal elastase 1 (r = 0.2616 and 0.2486, respectively, P < 0.05).The current findings indicate that patients with CP have gut microbiota dysbiosis that is partly affected by pancreatic exocrine function.
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