佐剂
医学
生物相容性
壳聚糖
材料科学
生物医学工程
药品
纳米技术
化学
药理学
肿瘤科
生物化学
冶金
作者
Chan Feng,Jun Ouyang,Zhongmin Tang,Na Kong,Yuan Liu,Li Fu,Xiaoyuan Ji,Tian Xie,Omid C. Farokhzad,Wei Tao
出处
期刊:Matter
[Elsevier]
日期:2020-07-01
卷期号:3 (1): 127-144
被引量:191
标识
DOI:10.1016/j.matt.2020.04.022
摘要
Germanene (Ge) is a newly discovered two-dimensional (2D) monoelemental material whose biomedical applications remain largely unexplored. Here, we provide the proof-of-principle evidence of a 2D Ge-based strategy for surgical adjuvant treatment. The exfoliated Ge nanosheets (NSs) exhibited high drug-loading capacity, multiresponsive (pH- and near-infrared [NIR]-sensitive) drug-release behavior, NIR-triggered deep tumor penetration, good biocompatibility, and excellent multimodal imaging-guided treatment. When combined with hydrogel (composed of clinically approved agarose and chitosan), the developed drug-loaded [email protected] was coated on the postoperative wound surface after tumor removal. Followed by NIR irradiation, the generated local hyperthermia and NIR-triggered drug release achieved immediate residual tumor-eliminating and bacteria-killing effects, while the hydrogel served as a therapeutic reservoir for long-lasting antitumor and bactericidal effects. In summary, this is the first application of 2D Ge-based surgical adjuvant treatment, potentially marking a jumping-off point for future studies on biomedical applications of Ge.
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