纳米棒
光热治疗
过氧化氢酶
生物相容性
材料科学
辐照
纳米技术
活性氧
光动力疗法
超氧化物歧化酶
化学
光化学
生物化学
酶
核物理学
冶金
有机化学
物理
作者
Seoung-Hun Kang,Yeong‐Gyu Gil,Dal‐Hee Min,Hongje Jang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2020-03-20
卷期号:14 (4): 4383-4394
被引量:49
标识
DOI:10.1021/acsnano.9b09974
摘要
Nanozymatic reactions that produce or consume oxygen (O2) or reactive oxygen species (ROS) consist of oxidase, peroxidase, superoxide dismutase (SOD), and catalase-type activity. Although extensive studies were conducted to overcome hypoxia through nanozymatic reactions, the construction of an ideal system is challenging, given that the reactants and products are arranged in a recurring structure for continuous consumption in a full cycle. In this study, speckled Ru–Te hollow nanorods were prepared through solvothermal galvanic replacement against Te nanorod templates with high yield and robustness. From their multicompositional characteristics, nonrecurring peroxidase-SOD-catalase-type nanozymatic properties were identified with photothermal and photodynamic feasibility over a wide range of laser irradiation wavelengths. Owing to the excellent colloidal stability and biocompatibility, the proposed Ru–Te-based nanozymatic platform was highly effective in hypoxic pancreatic cancer phototherapy in vitro and in vivo by near-infrared laser irradiation mediated photothermal and photodynamic combination treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI