[Research progress of intense pulsed light treatment on meibomian gland dysfunction and relevant dry eye diseases].

Intense pulsed light (IPL) is a broad spectrum incoherent light which is produced by high-output xenon lamp. Since the invention of the first-generation IPL in 1994, IPL technology has been developing rapidly and extensively utilized in multiple fields relevant to dermatology across the world. In 2004, the fourth-generation IPL system was introduced with the optimal pulse technology (OPT) and has soon been used for cosmetic purposes all over the world. In 2002, Dr. Toyos found that the meibomian gland dysfunction (MGD) and dye eye disease (DED)symptoms of the rosacea patients who received IPL treatment have been improving significantly, therefore he started to explore the application of IPL system to treatment of dry eye disease. Several recent clinical studies have demonstrated the therapeutic potential of IPL for improving the symptoms and signs of MGD and DED. However, the published data of IPL treatment for MGD and DED is limited, the mechanism of IPL treatment for MGD and DED remained unclear and more relevant researches needed to be done in the future. This article discusses the clinical application history and general mechanism of IPL, and introduces the treatment of IPL for MGD and DED. (Chin J Ophthalmol, 2018, 54: 140-143).强脉冲光是指高输出功率氙灯产生的宽谱非相关光。自1994年第一代强脉冲光技术推出后，该技术迅速发展，推广至皮肤科多个领域。2004年优化脉冲技术被推出后，强脉冲光更是在全世界美容领域得到广泛应用。2002年Toyos发现经过强脉冲光治疗后的酒糟鼻患者的睑板腺功能障碍及干眼症状得到了明显改善，开始将强脉冲光应用于眼科领域。近年来临床研究显示，强脉冲光可以明显改善睑板腺功能障碍及其相关干眼患者的眼部症状及体征。但相关研究较少，且作用机制尚不完全清楚，仍需更加深入的研究。本文阐述了强脉冲光的临床应用历程、一般作用原理以及治疗睑板腺功能障碍及蒸发过强型干眼的相关应用。（中华眼科杂志，2018，54：140-143）.