医学
汤剂
内科学
胃肠病学
萎缩性胃炎
中医药
幽门螺杆菌
肠化生
法莫替丁
病态的
胃粘膜
治疗效果
胃炎
胃
病理
替代医学
作者
Xiyong Wu,Xian Li,Zhongqin Dang,Wen-Zhao Luo,Chang-Pu Zhao,Kun Yu
出处
期刊:PubMed
日期:2017-12-01
卷期号:42 (24): 4882-4887
被引量:2
标识
DOI:10.19540/j.cnki.cjcmm.20170919.004
摘要
To explore the therapeutic effect and security of Zisheng decoction recipein treatment of the chronic atrophic gastritis (CAG) with intestinal metaplasia(IM). A total of 147 eligible cases were randomly divided into the traditional Chinese medicine group, Western medicine group and the combined group,47 cases in each group. Zisheng decoction recipe, famotidine, as well as Zisheng decoction recipe + famotidine were respectively given in the above three groups, with a treatment course of 30 d. The symptoms of traditional Chinese medicine, pathological score of gastric mucosa and the negative rate of Helicobacter pylori before and after treatment were observed in each group.The changes in pepsinogen Ⅰ (PGⅠ), pepsinogen Ⅱ (PGⅡ), gastrin-17 (GAS-17) and endothelin-1 (ET-1)were also detected to compare the efficient and safety indexes in the three groups. The combined group was better than the traditional Chinese medicine groupand the Western medicine group in total effective rate (P<0.05), pathological score of gastric mucosa and the negative rate of Helicobacter pylori, and serum indexes improvement (P<0.05). The improvement in TCM symptom score was more obvious in traditional Chinese medicine group and combined group than the Western medicine group (P<0.05). In the comparison ofincidence of complications,heart, liver and renal dysfunction, the traditional Chinese medicine group (2 case,4.8%)< the combined group (7 case,15.2%)
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