纳米载体
材料科学
过氧化脂质
过氧化物
癌症治疗
钙
活性氧
生物物理学
癌症研究
药物输送
纳米颗粒
过氧化氢
癌症
纳米技术
细胞毒性
脂质体
作者
Chuanchuan He,Xiaojuan Zhang,Chen Chen,Xiaoguang Liu,Yan Chen,Ruicong Yan,Ting Fan,Yongkang Gai,Robert J. Lee,Xiang Ma,Jun Luo,Yao Lu,Tan Yang,Guangya Xiang
标识
DOI:10.1016/j.actbio.2020.12.036
摘要
The unfavorable factors in tumor microenvironment such as hypoxia and limited H2O2 levels greatly impede the anticancer efficacy of chemotherapy and chemodynamic therapy (CDT). To address these issues and achieve O2/H2O2-sufficient chemo/chemodynamic combination therapy, we synthesized a solid lipid monostearin coated calcium peroxide (CaO2) nanocarrier for the co-delivery of a chemotherapeutic drug doxorubicin (DOX) and a biocompatible Fenton catalyst iron-oleate complex. Specifically, the solid lipid shells of nanoparticles could disintegrate in lipase-overexpressed cancer cells to release iron-oleate and expose CaO2 cores. Afterwards, the uncovered CaO2 responded to the acidic aqueous environment within cancer cells, leading to the release of DOX molecules and generation of H2O2. Based on Fenton reactions, Fe3+ liberated from iron-oleate reacted with H2O2 to produce O2 for hypoxia-relieved chemotherapy, and Fe2+ for the catalytic generation of hydroxyl radical to initiate CDT. Both treatments synergistically contribute to the enhanced antitumor outcomes.
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