医学
阿扎胞苷
髓系白血病
维持疗法
完全缓解
肿瘤科
白血病
内科学
化疗
生物
DNA甲基化
遗传学
基因表达
基因
作者
Andrew H. Wei,Hartmut Döhner,Christopher Pocock,Pau Montesinos,Boris V. Afanasyev,Hervé Dombret,Farhad Ravandi,Hamid Sayar,Jun‐Ho Jang,Kimmo Porkka,Dominik Selleslag,Irwindeep Sandhu,Mehmet Turgut,Valentina Giai,Yishai Ofran,Merih Kızıl Çakar,Aïda Botelho de Sousa,Justyna Rybka,Chiara Frairia,Lorenza Borin
标识
DOI：10.1056/nejmoa2004444
摘要
CC-486 maintenance therapy was associated with significantly longer overall and relapse-free survival than placebo among older patients with AML who were in remission after chemotherapy. Side effects were mainly gastrointestinal symptoms and neutropenia. Quality-of-life measures were maintained throughout treatment. (Supported by Celgene; QUAZAR AML-001 ClinicalTrials.gov number, NCT01757535.).
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(2025-6-4)
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