透皮
角质层
药物输送
纳米技术
渗透
药品
医学
生物医学工程
药理学
材料科学
化学
膜
生物化学
病理
作者
Lívia Neves Borgheti-Cardoso,Tamara Ângelo,Guilherme M. Gelfuso,Renata Fonseca Vianna Lopez,Taís Gratieri
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2016-09-02
卷期号:17 (13): 1545-1559
被引量:12
标识
DOI:10.2174/1389450116666151019095121
摘要
Topical and transdermal delivery has been studied over last decades and it presents advantages for the treatment of several disorders, macromolecules delivery and vaccination. The greatest challenge is to overcome the stratum corneum (SC) barrier. Compared to traditional topical formulation strategies, nano /microsystems offer advantages such as increased stability, increased loading dose, coverage of undesired colors, reduced toxicity and prolonged release of active agents. However, there are no conclusive studies demonstrating the ability of such systems to penetrate the skin in relevant therapeutic amounts. The use of physical methods holds great promise for enhancing skin permeation through the SC and for targeting hair follicles. This review discusses the characteristics and feasibility of using a dual approach employing the application of physical methods of permeation enhancement to enable the topical or transdermal delivery of drug-loaded nano/microsystems.
科研通智能强力驱动
Strongly Powered by AbleSci AI