Melasma is a fairly common pathology that refers to acquired melanin hyperpigmentation with clinical symptoms affecting exclusively the skin and manifested in the form of spotty elements with color variations from light to dark brown and typical localization of the pathological process on the skin of the face. In this study, we assessed the effectiveness of the developed combined therapy method using dermatocosmetics, IPL therapy and laser therapy with a neodymium laser. The overall therapeutic effectiveness in accordance with the dynamics of the MASI index was 59.6 %, the MSI index – 77 %, and the MELASQoL – 74.2 %.