Synthesis of N-formyl dihydropyrazoles as urease inhibitors

Abstract In this study dihydropyrazole based derivatives were synthesized from substituted chalcone through Michael addition reaction. Urease inhibition activity of the compounds was evaluated, revealing that most compounds exhibited moderate inhibition. Among the synthesized compounds, 2b, 2m, and 2n demonstrated exceptional potency with IC 50 values of 5.21 ± 0.91 µM, 6.21 ± 0.10 µM, and 5.21 ± 0.81 µM, respectively. Thus, these findings suggest that dihydropyrazole represent a promising scaffold for the development of novel urease inhibitors.