SWI/SNF chromatin remodeling complexes as key regulators of CD8+ T cell fate

CD8+ T cell fate is tightly regulated by epigenetic modification. In this issue of Immunity, McDonald et al. and Baxter et al. demonstrate that the chromatin remodeling complexes cBAF and PBAF control proliferation, differentiation, and function of cytotoxic T cells in response to infection as well as cancer. CD8+ T cell fate is tightly regulated by epigenetic modification. In this issue of Immunity, McDonald et al. and Baxter et al. demonstrate that the chromatin remodeling complexes cBAF and PBAF control proliferation, differentiation, and function of cytotoxic T cells in response to infection as well as cancer. The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cellsBaxter et al.ImmunityJune 13, 2023In BriefEpigeneic factors regulate key transitions in CD8+ T cell exhaustion. Baxter et al. find that two versions of SWI/SNF chromatin-remodeling complexes direct distinct epigenetic checkpoints in the development of exhaustion. Whereas BAF is required for early responses, PBAF protects the stem-cell-like population responsive to PD-1 checkpoint blockade. Full-Text PDF