医学
间质性肺病
CD8型
肺癌
免疫疗法
细胞因子
免疫系统
T细胞
肺
过敏性肺炎
癌症研究
免疫学
内科学
肿瘤科
作者
Tomomi Isono,Kota Iwahori,Masahiro Yanagawa,Yoko Yamamoto,Mari Tone,Miya Haruna,Michinari Hirata,Emiko Fukui,Tōru Kimura,Takashi Kanou,Naoko Ose,Soichiro Funaki,Yoshito Takeda,Eiichi Morii,Atsushi Kumanogoh,Yasushi Shintani,Hisashi Wada
出处
期刊:Lung Cancer
[Elsevier]
日期:2023-08-01
卷期号:182: 107278-107278
标识
DOI:10.1016/j.lungcan.2023.107278
摘要
Objectives Limited treatment options are available for non-small cell lung cancer (NSCLC) patients with interstitial lung disease (ILD). The rationale for immunotherapy and its adverse events for NSCLC with ILD remains unclear. In this study, we examined T cell profiles and functions in the lung tissues of NSCLC patients with or without ILD to provide evidence for the potential mechanism of immune checkpoint inhibitor (ICI)-related pneumonitis in NSCLC patients with ILD. Material and Methods We investigated T cell immunity in the lung tissues of NSCLC patients with ILD to support the application of immunotherapy for these patients. We analyzed T cell profiles and functions in surgically resected lung tissues from NSCLC patients with and without ILD. The T cell profiles of infiltrating cells in lung tissues were analyzed by flow cytometry. T cell functions were measured based on cytokine production by T cells stimulated with phorbol 12-myristate 13-acetate and ionomycin. Results The percentages of CD4+ T cells expressing immune checkpoint molecules (Tim-3, ICOS, and 4-1BB), CD103+CD8+ T cells, and regulatory T (Treg) cells were higher in NSCLC patients with than in those without ILD. A functional analysis of T cells in lung tissues indicated that CD103+CD8+ T cells positively correlated with IFNγ production, whereas Treg cells negatively correlated with IFNγ and TNFα production. Cytokine production by CD4+ and CD8+ T cells did not significantly differ between NSCLC patients with and without ILD, except for TNFα production by CD4+ T cells being lower in the former than in the latter. Conclusion In NSCLC patients with ILD stable for surgery, T cells were active participants and balanced in part by Treg cells in lung tissues, suggesting the potential development of ICI-related pneumonitis in NSCLC patients with ILD.
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