Clocking Recurrence: Circulating Tumor HPV DNA Kinetics in Anal Cancer

Abstract Detection of circulating tumor human papillomavirus DNA (ctHPVDNA) three months after completing definitive chemoradiation for localized anal squamous cell carcinoma associates with disease recurrence and inferior recurrence-free survival. These findings provide valuable insights into the temporal significance of ctHPVDNA detection in anal cancer and its potential implications for early intervention.