Ganoderic acid A regulates CSF1R to reprogram tumor-associated macrophages for immune therapy of hepatocellular carcinoma

Our findings suggest that GAA exerts immunotherapeutic effects in HCC by regulating macrophage polarization through CSF1R inhibition. As a promising natural bioactive compound with the potential to modulate the TME of HCC, GAA may provide novel insights into HCC immunotherapy through the reprogramming of TAMs.