Kaempferol Treatment and Rehabilitation Training Recover the Neurological and Motor Functions in Cerebral Ischemic Injury-induced Rats via MyD88/TLR-4 Pathway

Background Cerebral ischemic stroke, a devastating neurological condition, occurs when the blood supply to a specific region of the brain is interrupted, leading to a cascade of complex physiological and biochemical processes that ultimately result in cellular dysfunction and tissue damage. Objectives This study was dedicated to assessing the beneficial activities of kaempferol along with rehabilitation training in improving cerebral ischemic stroke-induced neurological complications in the experimental rat model. Materials and Methods The experimental rats underwent middle cerebral artery occlusion to initiate ischemic stroke. The experimental rats subsequently underwent kaempferol treatment and rehabilitation training alone or in combination. The experimental rats’ neurobehavioral, balance beam, and rotary stick scores were evaluated. The concentrations of inflammation-associated proteins and apoptotic protein levels were assessed in the brain hippocampal tissues of the experimental rats using commercial diagnostic kits. Results The kaempferol treatment and rehabilitation training alone or in combination significantly decreased the neurobehavioral, balance beam, and rotary stick scores in the rats with ischemic stroke. Furthermore, the kaempferol treatment and rehabilitation training alone or in combination successfully diminished the inflammation-associated protein levels. It regulated the pro- and anti-apoptotic protein concentrations in the brain hippocampal tissues of the rats with cerebral ischemic stroke. Conclusion The present research highlighted that kaempferol treatment and rehabilitation training alone or in combination can enhance the regaining of neurobehavioral and motor functions in rats with ischemic stroke. The present findings may facilitate the advancement of kaempferol as a new therapeutic candidate to treat ischemic stroke.