微卫星不稳定性
免疫疗法
医学
结直肠癌
癌症
肿瘤科
微卫星
癌症研究
内科学
生物
遗传学
基因
等位基因
作者
Yan-Jie Han,Chi-Yun Shao,Ying Yao,Zhe Zhang,Mingzhi Fang,Tao Gong,Yajie Zhang,Min Li
标识
DOI:10.1093/postmj/qgad136
摘要
Abstract In recent years, immunotherapy strategies based on immune checkpoint inhibitors have yielded good efficacy in colorectal cancer (CRC)especially in colorectal cancer with microsatellite instability-high. However, microsatellite-stable (MSS) CRCs account for about 85% of CRCs and are resistant to immunotherapy. Previous studies have shown that compared with MSS CRC, high microsatellite instability CRC possesses a higher frequency of mutations and can generate more neoantigens. Therefore, improving the sensitivity of immunotherapy to MSS CRC is a hot topic which is crucial for the treatment of MSS CRC. This review aims to discuss the factors contributing to MSS CRC insensitivity to immunotherapy and explored potential solutions to overcome immunotherapy resistance.
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