This study presents a comparative study of Photonic Crystal Fibers (PCFs) infiltrated with nonlinear organic liquids nitrobenzene and ethanol for near infrared to mid-infrared (MIR) supercontinuum generation (SCG). The liquids in the air holes enable high nonlinear and tunable properties. The enhancement of nonlinear properties results in a broader SC spectrum with low pump power and low attenuation. To analyze the impact of infiltration, a full vectorial finite element method (FEM) has been employed. For silica-based PCF (#A), dispersion around [Formula: see text][Formula: see text]ps/nm/km, effective mode area as 6.57[Formula: see text][Formula: see text]m 2 and nonlinear coefficient as 1234.18[Formula: see text]W[Formula: see text]km[Formula: see text] is obtained at 1.55[Formula: see text][Formula: see text]m. For other infiltrated designs (#B), (#C) and (#D) at 1.55 [Formula: see text]m dispersion around [Formula: see text][Formula: see text]ps/nm/km, [Formula: see text][Formula: see text]ps/nm/km, [Formula: see text][Formula: see text]ps/nm/km, effective mode area as 1.45[Formula: see text][Formula: see text]m 2 and nonlinear coefficient as 5596.22[Formula: see text]W[Formula: see text]km[Formula: see text], 5569.71[Formula: see text]W[Formula: see text]km[Formula: see text] and 5584.28[Formula: see text]W[Formula: see text]km[Formula: see text] are obtained, respectively. A broadband supercontinuum spanning from 1.3–1.8[Formula: see text][Formula: see text]m for #A, 1.0–2.4[Formula: see text][Formula: see text]m for #B, 1.2–2.5[Formula: see text][Formula: see text]m for #C and 0.9–2.5[Formula: see text][Formula: see text]m for #D is obtained by using a fiber length of 4[Formula: see text]mm to 8[Formula: see text]mm with 50[Formula: see text]fs secant laser pulse source and a pump power of 600[Formula: see text]W to 800[Formula: see text]W. The suggested PCF design can be employed for various critical applications involving the detection of explosives, various gases, cancers, ulcers and enhanced monitoring systems for food quality detection.