Un-FASN-ing cancer’s seat belt: Linking lipid metabolism and antigen presentation

MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al. 1 Huang L. Zhang J. Wei B. Chen S. Zhu S. Qi W. Pei X. Li L. Liu W. Wang Y. et al. Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism. Cell Chem. Biol. 2023; 30: 1076-1089https://doi.org/10.1016/j.chembiol.2023.05.003 Abstract Full Text Full Text PDF Scopus (0) Google Scholar report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (FASN), resulting in inhibition of tumor growth. Targeting this link between lipid metabolism and antigen presentation may improve response to immunotherapy. MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al. 1 Huang L. Zhang J. Wei B. Chen S. Zhu S. Qi W. Pei X. Li L. Liu W. Wang Y. et al. Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism. Cell Chem. Biol. 2023; 30: 1076-1089https://doi.org/10.1016/j.chembiol.2023.05.003 Abstract Full Text Full Text PDF Scopus (0) Google Scholar report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (FASN), resulting in inhibition of tumor growth. Targeting this link between lipid metabolism and antigen presentation may improve response to immunotherapy. Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolismHuang et al.Cell Chemical BiologyMay 25, 2023In BriefHuang et al. identified three small-molecule MHC-II inducers that effectively increase tumor-infiltrating T cells and enhance anti-cancer immunity, with FASN-mediated MHC-II expression as the underlying mechanism. Full-Text PDF