光动力疗法
河马信号通路
合理设计
机制(生物学)
荧光
化学
转录因子
癌症治疗
生物物理学
纳米技术
细胞凋亡
细胞生物学
癌症
计算生物学
生物
材料科学
基因
生物化学
遗传学
认识论
物理
哲学
量子力学
有机化学
作者
Shiping Yang,Hongchi Yu,Junkai Liu,Li Ma,Zhe Hou,Jia Ma,Michael Z. Miao,Ryan T. K. Kwok,Jianwei Sun,Herman H. Y. Sung,Ian D. Williams,Jacky W. Y. Lam,Xiaoheng Liu,Ben Zhong Tang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-10-30
卷期号:17 (21): 21182-21194
标识
DOI:10.1021/acsnano.3c05080
摘要
The technology of aggregation-induced emission (AIE) presents a promising avenue for fluorescence imaging-guided photodynamic cancer therapy. However, existing near-infrared AIE photosensitizers (PSs) frequently encounter limitations, including tedious synthesis, poor tumor retention, and a limited understanding of the underlying molecular biology mechanism. Herein, an effective molecular design paradigm of anion-π+ interaction combined with the inherently crowded conformation that could enhance fluorescence efficacy and reactive oxygen species generation was proposed through a concise synthetic method. Mechanistically, upon photosensitization, the Hippo signaling pathway contributes to the death of melanoma cells and promotes the nuclear location of its downstream factor, yes-associated protein, which regulates the transcription and expression of apoptosis-related genes. The finding in this study would trigger the development of high-performance and versatile AIE PSs for precision cancer therapy based on a definite regulatory mechanism.
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