Pyruvate dehydrogenase phosphatase

Four classes of protein serine/threonine phosphatases have been identified in eukaryotic cells on the basis of substrate specificities and sensitivity to activators and inhibitors (Cohen, 1989; Shenolikar and Nairn, 1991). Protein phosphatase 1 is sensitive to the thermostable proteins inhibitor 1 and inhibitor 2, and protein phosphatases 1 and 2A are sensitive to okadaic acid. Protein phosphatase 2B is Ca 2+ /calmodulin-regulated and protein phosphatase 2C is Mg 2+ -dependent. The protein serine/threonine phosphatases of known sequence comprise two distinct gene families, a major family that includes protein phosphatases 1, 2A, and 2B and isoforms thereof, and a smaller family that includes protein phosphatase 2C and pyruvate dehydrogenase (PDH) phosphatase. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.