Morphological anomalies in the lymph nodes of 13-month-old thymus-grafted nude mice.

The purpose of the present work was to investigate whether the grafting of a thymus to 7-day-old BALB/cByJ nude mice prevents the occurrence of the nodal anomalies recently observed in non-grafted nude mice. We found that the anomalies were still present, but attenuated, in the grafted mice. Furthermore, we observed differences between anomalies occurring in grafted and in non-grafted nude mice. The differences appear to be interrelated and to result from changes in the pattern of lymphocyte migration in the nodes of grafted nude mice, due to a lesser deficiency of the immune system.