Resistant Starch reduces postprandial glycemic and insulinemic response and increases satiety in humans

Objective To assess the dose‐response effect of adding resistant starch to drinks on postprandial glycemia, insulinemia, satiety and post‐load ad libitum food intake. Methods 22 healthy "unrestrained eaters" (13 male, 9 female, age 26±4y; BMI 23.7±2.4kg/m ² ) consumed meals containing 0g, 5g, 15g and 25g of PROMITOR(tm) RS in a randomized, double blind, crossover study. Using a visual analogue scale (VAS), subjects rated their satiety level and symptoms at 0, 15, 30, 45, 60, 90 and 120 min after eating. Blood samples were taken simultaneously. Using the satiety ratings, the satiety quotient and appetite score were calculated. Two hours after eating, subjects were given an ad libitum meal and total energy intake was recorded. Results All meals were well tolerated and no significant adverse symptoms were reported. Compared to the control, the 25g dose of RS resulted in significantly lower blood glucose (P≤0.002) and serum insulin levels at 90min and 120 min. In addition the satiety quotient for mean appetite score for the 25g RS dose was significantly higher (P≤0.05) compared to the control at 15min and 45 min. However second meal ad libitum meal total energy intake was not different between treatments. Conclusions The inclusion of RS may effectively reduce the postprandial glycemic and insulinemic response of meals and increase satiety without adverse symptoms.