Abstract 1317: A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9)-binding Antibody, That Structurally Mimics the Egf-a Domain of the LDL-receptor, Lowers LDL-cholesterol in a Transgenic Mouse Model and in Rhesus Monkeys
作者
Jon H. Condra,Andrea Carfı́,Stefania DiMarco,Ni Yan,Weirong Wang,Matthew J. Bottomley,Ray Rosa,Vivienne Mendoza,Shilpa Pandit,Xun Shen,Liwen Zhang,Joseph C. Santoro,Timothy S. Fisher,Cinzia Volpari,Dale Lewis,Holly A. Hammond,Dana D. Wood,Sharon Lobo,Douglas Wisniewski,Kimberly Michel
出处
期刊：Circulation [Lippincott Williams & Wilkins] 日期：2009-11-03卷期号：120被引量：2
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL-C levels by binding to cell surface LDL-receptor protein (LDLR) and is an important therapeutic target for treating coronary...
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