Suspect, non-target and target screening of pharmaceuticals and personal care products (PPCPs) in a drinking water system

Drinking water quality and safety are very important in protecting human health. Chemical contaminants in drinking water system have become an increasing concern. Our knowledge about what chemicals are present in drinking water is still limited. Here we screened chemicals of emerging concern in a conventional drinking water system based on suspect, non-target screening and target analysis, and assessed their variations in different seasons and different treatment units. Overall, 720 chemicals were identified with HRMS databases from the suspect and non-target screening and 48 chemicals in five categories were further confirmed with the high confidence level, with predominance of pharmaceuticals and personal care products (PPCPs) and pesticides. Four compounds are newly found in aquatic environment with no literature or chemical occurrence data record. Temporal variations and variable removals were observed for these chemicals in the system. Target analysis of 110 PPCPs showed detection of 21, 19 and 22 compounds in the drinking water treatment plant with a concentration range of 0.11-844 ng/L in the three seasons, but only 8, 9 and 15 compounds detected in tap water (0.16-32.5 ng/L). The variations of the detected chemicals were less obvious in tap water, with most having concentrations below 2 ng/L. The results indicated efficient removal for most PPCPs in the drinking water system. The findings from this study demonstrated the strong capability of combined non-target screening and target analysis in identifying and assessing various organic chemicals in drinking water system.