Copper‐Catalyzed One‐Pot Cascade Cyclization for the Synthesis of Isoindolo[2,1‐a]quinoxalines

Abstract A copper‐catalyzed one‐pot cascade cyclization of 2‐(1‐(acetyloxy)propargyl)benzaldehydes with o ‐phenylenediamines for an access to substituted isoindolo[2,1‐ a ]quinoxalines has been developed. The reaction features readily available starting materials, simple operational procedure, and broad substrate scopes. Under optimal conditions, various isoindolo[2,1‐ a ]quinoxalines were afforded in 41–88% yields. magnified image