化学
废止
合成子
吡啶
戒指(化学)
分子
二甲基甲酰胺
Atom(片上系统)
药物化学
立体化学
有机化学
催化作用
溶剂
计算机科学
嵌入式系统
作者
Miaodong Su,Haiping Liu,Zhongzhong Cao,Yufeng Liu,Hui Li,Zhiwen Nie,Tonglin Yang,Weiping Luo,Qiang Liu,Can‐Cheng Guo
标识
DOI:10.1021/acs.joc.1c01550
摘要
Two C═C bond participation in annulation to pyridines using N,N-dimethylformamide (DMF) as the N1 and C4 synthons has been carried out. In this reaction, DMF contributed one N atom and one C atom to two disconnected positions of pyridine ring, with no need for an additional nitrogen source. Two C═C bonds in two molecules of substituted styrenes offered four carbon atoms in the presence of iodine and persulfate. With the optimized conditions in hand, both symmetric and unsymmetric diaryl-substituted pyridines were obtained in useful yields. On the basis of relevant literature and a series of control experimental results, a possible mechanism was proposed in this work, which may demonstrate how DMF provides both N1 and C4 sources.
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