肝细胞癌
非编码RNA
生物
长非编码RNA
小RNA
癌症
计算生物学
生物信息学
小核仁RNA
核糖核酸
癌症研究
遗传学
基因
作者
Xiujuan Sun,Anshoo Malhotra
标识
DOI:10.1615/jenvironpatholtoxicoloncol.2018025223
摘要
Hepatocellular carcinoma (HCC) has emerged as a prominent cancer in both developing and developed countries. Due to the increasing burden of HCC patients, massive resources are expended in their management. Furthermore, there is an urgent need to identify new molecular players that could be targeted to halt cancer development in the early phases. Noncoding RNAs (ncRNAs), which were previously thought to lack value, have the potential to play a pivotal role in the present era of personalized and translational research. Several recent studies have reported the involvement of ncRNAs in initiating, regulating, and nurturing HCC. This review provides insights regarding recently reports of noncoding RNAs and their diverse roles in initiation and development of hepatocellular carcinoma.
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