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Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese

医学 亚临床感染 内科学 优势比 肌萎缩 心脏病学
作者
Yūji Shimizu,Shimpei Sato,Jun Koyamatsu,Hirotomo Yamanashi,Mako Nagayoshi,Koichiro Kadota,Shin‐ya Kawashiri,Keita Inoue,Yasunobu Nagata,Takahiro Maeda
出处
期刊:Oncotarget [Impact Journals LLC]
卷期号:8 (41): 69362-69369 被引量:25
标识
DOI:10.18632/oncotarget.20618
摘要

// Yuji Shimizu 1,2 , Shimpei Sato 1 , Jun Koyamatsu 3 , Hirotomo Yamanashi 3 , Mako Nagayoshi 1 , Koichiro Kadota 1 , Shin-Ya Kawashiri 1 , Keita Inoue 1 , Yasuhiro Nagata 4 and Takahiro Maeda 1,3 1 Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan 2 Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan 3 Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan 4 Center for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Correspondence to: Yuji Shimizu, email: // Keywords : atherosclerosis, handgrip, hypertension, platelet, sarcopenia, Gerotarget Received : June 21, 2017 Accepted : August 16, 2017 Published : September 01, 2017 Abstract Age-related disruption of microvascular endothelium exacerbates hypertension and sarcopenia; and atherosclerosis is a well-known biological response to vascular endothelial injury. Therefore, prevalence of atherosclerosis among hypertensive elderly subjects may partly indicate the presence of an appropriate response to endothelial injury. We conducted a cross-sectional study of 795 elderly hypertensive Japanese subjects aged 60-89 years. Since platelet level is an indicator of vascular repair activity, subjects were stratified by platelet counts. No significant association between handgrip strength and subclinical carotid atherosclerosis (carotid intima-media thickness (CIMT) ≥1.1mm) was observed for subjects with lower platelet counts, while a significant positive association was observed for subjects with higher platelets. Adjusted odds and 95% confidence intervals of subclinical carotid atherosclerosis for 1 standard deviation increments in handgrip strength were 0.86 (0.61, 1.22) for subjects with lower platelets and 1.82 (1.26, 2.64) for subjects with higher platelets. A positive association between handgrip strength and subclinical carotid atherosclerosis exists in hypertensive elderly subjects with higher, but not lower, platelet counts. These results lead us to speculate that subjects with a beneficial influence on prevention of sarcopenia (maintenance of handgrip strength) may possess the capacity of active endothelial repair that causes atherosclerosis.
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